COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis†
نویسندگان
چکیده
منابع مشابه
The COP9 signalosome is a highly conserved eight-subunit protein
The COP9 signalosome was originally identified as a repressor of light mediated development in Arabidopsis (Wei and Deng, 1992; Wei et al., 1994a; Wei et al., 1994b; Chamovitz et al., 1996). Plant development is highly plastic and optimized according to environmental cues, of which light plays a dominant role (Kendrick and Kronnberg, 1994). In response to light, Arabidopsis seedlings undergo ph...
متن کاملThe COP9 signalosome is essential for development of Drosophila melanogaster
The COP9 signalosome (originally described as the COP9 complex) is an essential multi-subunit repressor of light-regulated development in plants [1] [2]. It has also been identified in mammals, though its role remains obscure [3] [4] [5]. This complex is similar to the regulatory lid of the proteasome and eIF3 [5] [9] [10] [11] [12] and several of its subunits are known to be involved in kinase...
متن کاملProteomic analysis reveals that COP9 signalosome complex subunit 7A (CSN7A) is essential for the phase transition of migratory locust
The migratory locust displays a reversible, density-dependent transition between the two phases of gregaria and solitaria. This phenomenon is a typical kind of behavior plasticity. Here, we report that COP9 signalosome complex subunit 7A (CSN7A) is involved in the regulation of locust phase transition. Firstly, 90 proteins were identified to express differentially between the two phases by quan...
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RNA-binding proteins (RBPs) play important roles for generating various cell types in many developmental processes, including eggs and sperms. Nanos is widely known as an evolutionarily conserved RNA-binding protein implicated in germ cell development. Mouse NANOS2 interacts directly with the CCR4-NOT (CNOT) deadenylase complex, resulting in the suppression of specific RNAs. However, the mechan...
متن کاملThe Arabidopsis COP9 signalosome subunit 7 is a model PCI domain protein with subdomains involved in COP9 signalosome assembly.
The COP9 Signalosome (CSN) is a multiprotein complex that was originally identified in Arabidopsis thaliana as a negative regulator of photomorphogenesis and subsequently shown to be a general eukaryotic regulator of developmental signaling. The CSN plays various roles, but it has been most often implicated in regulating protein degradation pathways. Six of eight CSN subunits bear a sequence mo...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2019
ISSN: 0006-3363,1529-7268
DOI: 10.1093/biolre/ioz154